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MicroRNA profiles in nasal mucosa of patients with allergic and nonallergic rhinitis and asthma
Article first published online: 23 MAY 2013
© 2013 ARS-AAOA, LLC
International Forum of Allergy & Rhinology
Volume 3, Issue 8, pages 612–620, August 2013
How to Cite
How to Cite this Article: MicroRNA profiles in nasal mucosa of patients with allergic and nonallergic rhinitis and asthma. Int Forum Allergy Rhinol. 2013;3:612-620., , , etc.
Potential conflict of interest: None provided.
- Issue published online: 16 AUG 2013
- Article first published online: 23 MAY 2013
- Manuscript Accepted: 23 APR 2013
- Manuscript Revised: 4 APR 2013
- Manuscript Received: 15 FEB 2013
- immune system;
- nitric oxide;
- respiratory hypersensitivity
Rhinitis and asthma commonly coexist and are often regarded as “unified airways disease.” Evidence exists that microRNAs are important in controlling inflammatory processes, but little is known about their role in airway inflammation. The present study evaluated the inflammatory profiles of patients with allergic rhinitis (AR), with and without concomitant asthma, and of patients with nonallergic rhinitis (NAR).
We analyzed inflammatory cells, cytokines, and microRNAs from nasal biopsies and measured nasal nitric oxide (nNO) levels in 159 young adult subjects subdivided into 4 groups: (1) AR; (2) AR+asthma; (3) NAR; and (4) controls.
We observed the upregulation of T-helper 2 (Th2) cytokines and the trend of elevation of nNO levels in AR patients compared to controls. Subjects with current AR symptoms had increased levels of miR-155, miR-205, and miR-498, but reduced levels of let-7e. In addition, patients with positive skin prick test (SPT) reactions exhibited increased miR-155 and miR-205 expression and a decreased level of let-7e, compared to subjects with negative SPT findings. Concomitant asthma had little effect on the inflammatory profile of AR. No significant changes in inflammatory markers were found in NAR patients compared to healthy controls.
Our results suggest that microRNAs miR-155, miR-205, miR-498, and let-7e may be important in the allergic inflammation present in nasal mucosa. Regarding NAR, our findings support the view that mechanisms other than inflammation are pivotal.