Potential conflict of interest: None provided.
Effect of intranasal budesonide irrigations on intraocular pressure
Article first published online: 23 MAY 2013
© 2013 ARS-AAOA, LLC
International Forum of Allergy & Rhinology
Volume 3, Issue 9, pages 704–707, September 2013
How to Cite
How to Cite this Article: Effect of intranasal budesonide irrigations on intraocular pressure. Int Forum Allergy Rhinol. 2013;3:704-707., , , , .
Presented orally at the Combined Otolaryngology Spring Meetings (COSM), April 10–14, 2013, Orlando, FL.
- Issue published online: 17 SEP 2013
- Article first published online: 23 MAY 2013
- Manuscript Accepted: 24 APR 2013
- Manuscript Revised: 10 APR 2013
- Manuscript Received: 5 MAR 2013
- budesonide irrigations;
- chronic rhinosinusitis;
- nasal polyps;
- intraocular hypertension;
- intranasal steroids
Intranasal and oral corticosteroids are widely used in the management of chronic rhinosinusitis with nasal polyps (CRSwNP). Higher-dose topical nasal steroids (HDTNS) such as budesonide irrigations are increasingly used for long-term maintenance in these patients. Oral steroids have the potential to cause increased intraocular pressure (IOP) and glaucoma. It is unclear whether HDTNS have the same potential. The objective of this study was to determine the effect of intranasal budesonide irrigations on IOP.
Two groups of patients with CRSwNP treated with budesonide irrigations were prospectively enrolled. Patients with history of elevated IOP or glaucoma were excluded. Patients in group 1 had been using budesonide for at least 1 month and had IOP measured once at the time of enrollment. Group 2 consisted of patients who were placed on budesonide at the time of enrollment and had IOP measured both before and after at least 4 weeks of therapy.
Ten patients in group 1 and 8 patients in group 2 completed the study. In group 1, the average duration of therapy at enrollment was 6.3 months (1–22 months). Only 1 patient had a single eye pressure above 21 mmHg. None of the patients in group 2 had a significant change in IOP or IOP over 21 mmHg.
Intranasal budesonide irrigations given for a period of at least 1 month do not appear to increase IOP.