Funding sources for the study: American Academy of Otolaryngic Allergy research grant.
Optical rhinometry in nonallergic irritant rhinitis: a capsaicin challenge study
Article first published online: 3 JUN 2013
© 2013 ARS-AAOA, LLC
International Forum of Allergy & Rhinology
Volume 3, Issue 10, pages 795–800, October 2013
How to Cite
How to Cite this Article: Optical rhinometry in nonallergic irritant rhinitis: a capsaicin challenge study. Int Forum Allergy Rhinol. 2013;3:795–800., , , ,
Potential conflict of interest: None provided.
- Issue published online: 15 OCT 2013
- Article first published online: 3 JUN 2013
- Manuscript Accepted: 24 APR 2013
- Manuscript Revised: 30 MAR 2013
- Manuscript Received: 9 DEC 2012
- American Academy of Otolaryngic Allergy research grant
- optical rhinometry;
- nonallergic rhinitis;
- nasal provocation test;
- acoustic rhinometry;
Patients with nonallergic irritant rhinitis (NAIR) have symptoms of nasal congestion, nasal irritation, rhinorrhea, and sneezing in response to nasal irritants. We currently have no reliable objective means to quantify these patients’ subjective symptoms. In this study, we used the transient receptor potential vanilloid receptor (TRPV1) receptor agonist, capsaicin, as an intranasal challenge while comparing the changes in blood flow with optical rhinometry between subjects with NAIR and healthy controls (HCs).
Six HCs and 6 NAIR subjects were challenged intranasally with saline solution followed by increasing concentrations of capsaicin (0.005 mM, 0.05 mM, and 0.5 mM) at 15-minute intervals. We recorded maximum optical density (OD) and numeric analog scores (NAS) for nasal congestion, nasal irritation, rhinorrhea, and sneezing for each subject after each challenge. Correlations between NAS and maximum OD were calculated.
Maximum OD increased with increasing concentrations of intranasal capsaicin in NAIR subjects. There were significant differences in maximum OD obtained for 0.05 mM and 0.5 mM capsaicin between NAIR subjects and HCs. Significant differences were found in the NAS for nasal irritation at 0.005 mM, 0.05 mM, and 0.5 mM, and nasal congestion at 0.5 mM. Correlation between maximum OD and mean NAS was most significant for 0.05 mM capsaicin.
Optical rhinometry with intranasal capsaicin challenge could prove a viable option in the diagnosis of NAIR. Further studies will investigate its use to monitor a patient's response to pharmacologic therapy and provide further information about the underlying mechanisms of NAIR.