The impact of neo-osteogenesis on disease control in chronic rhinosinusitis after primary surgery

Authors

  • Peta-Lee Sacks MD,

    Corresponding author
    1. Department of Otolaryngology–Head and Neck Surgery, University of NSW, Sydney, Australia
    2. Department of Otolaryngology–Head and Neck Surgery, St. Vincent's Hospital, Sydney, Australia
    • Correspondence to: Peta-Lee Sacks, MD, Suite 12, The Madison, 25-29 Hunter St., Hornsby 2077, NSW, Australia; e-mail: p.sacks@student.unsw.edu.au

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  • Kornkiat Snidvongs MD,

    1. Department of Otolaryngology–Head and Neck Surgery, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia
    2. Department of Otolaryngology–Head and Neck Surgery, Faculty of Medicine, Chulalongkorn University, Thailand
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  • Darren Rom MD,

    1. Department of Otolaryngology–Head and Neck Surgery, University of Sydney, Sydney, Australia
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  • Peter Earls MD,

    1. Department of Otolaryngology–Head and Neck Surgery, St. Vincent's Hospital, Sydney, Australia
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  • Raymond Sacks MD,

    1. Department of Otolaryngology–Head and Neck Surgery, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia
    2. Department of Otolaryngology–Head and Neck Surgery, University of Sydney, Sydney, Australia
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  • Richard J. Harvey MD

    1. Department of Otolaryngology–Head and Neck Surgery, University of NSW, Sydney, Australia
    2. Department of Otolaryngology–Head and Neck Surgery, St. Vincent's Hospital, Sydney, Australia
    3. Department of Otolaryngology–Head and Neck Surgery, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia
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  • Potential conflict of interest: R.S. is a consultant for Medtronic and Nycomed, and on the speakers’ bureau for Merek Sharp Dolme and Arthrocare. R.J.H. has served on an advisory board for Schering Plough and Glaxo-Smith-Kline, is a previous consultant with Medtronic and Olympus, is on the speakers’ bureau for Merek Sharp Dolme and Arthrocare, and has received grant support from NeilMed.

Abstract

Background

Osteitic bone is a feature of chronic rhinosinusitis (CRS), potentially playing a role in pathogenesis. Although seen after previous endoscopic sinus surgery (ESS), it is also a de novo feature in patients without prior interventions. In these patients, osteitis is associated with high tissue and serum eosinophilia. However, the impact of osteitis on prognosis is unclear. This study investigates the clinical and endoscopic outcomes between patients with and without osteitis after primary ESS.

Methods

A prospective study of a cohort of previously unoperated patients with CRS undergoing ESS was performed. The sinuses were scored radiologically for osteitis using the Global Osteitis Score (GOS) and Kennedy Osteitis Score (KOS) preoperatively and were also scored dichotomously for the presence or absence of osteitis. Disease-specific quality of life (22-item Sino-Nasal Outcomes Test [SNOT-22]), nasal symptom score (NSS), endoscopic score (Lund-Kennedy), and clinical outcomes—including oral steroid use, frequency of nasal steroid irrigation, and infective exacerbations—were collected at baseline and 1 year postsurgery. The presence and extent of osteitis was assessed relative to clinical outcome.

Results

Fifty-three patients were included (41.5% female, age 47.4 ± 13.8 years), 42.9% of which had radiologic osteitis. There was no significant association between the presence or severity of osteitis at the time of surgery and SNOT-22, NSS, or endoscopy scores at 12 months postsurgery. However, the presence of osteitis was associated with the need for a course of oral steroid postsurgery (odds ratio [OR]=4.17; p = 0.026). High tissue eosinophilia could not predict this alone (p = 0.55). There was no significant relationship between osteitis and the frequency of steroid irrigations or infective exacerbations.

Conclusion

Osteitis in CRS is associated with the degree of eosinophilia and as a independent process it was associated with the need for a course of systemic corticosteroid over a 12-month period, but did it not affect overall disease control.

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