Potential conflict of interest: T.L.S. is supported by a grant from the NIH, National Institute on Deafness and Other Communication Disorders (NIDCD; 2R01 DC005805); public clinical trial registration (http://clinicaltrials.gov/show/NCT01332136; Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis); he is also a consultant for Intersect ENT (Palo Alto, CA.) which is not affiliated in any way with this investigation.
Chronic rhinosinusitis and sleep: a contemporary review
Version of Record online: 26 AUG 2013
© 2013 ARS-AAOA, LLC
International Forum of Allergy & Rhinology
Volume 3, Issue 11, pages 941–949, November 2013
How to Cite
How to Cite this Article: Chronic rhinosinusitis and sleep: a contemporary review. Int Forum Allergy Rhinol. 2013; 3: 941-949.,
- Issue online: 15 NOV 2013
- Version of Record online: 26 AUG 2013
- Manuscript Accepted: 26 JUL 2013
- Manuscript Revised: 25 JUN 2013
- Manuscript Received: 4 MAR 2013
- National Institute on Deafness
- NIDCD. Grant Number: 2R01 DC005805
Patients with chronic rhinosinusitis (CRS) exhibit centrally mediated behavioral changes commonly referred to as “sickness behavior.” Sleep alteration is a component of sickness behavior which is estimated to affect up to 70 million patients annually. Patients with CRS have poor sleep quality, and little is known about the underlying etiology and pathophysiology. This narrative review aims to further organize and present the current knowledge associating sleep and CRS.
A literature search was conducted of the OVID MEDLINE database using key search words including: “chronic rhinosinusitis,” “sleep,” “sleep disorders,” and “sleep dysfunction.” Additional keywords “nasal obstruction,” “nasal polyp,” and “fatigue” were identified and used to further delineate relevant articles.
The articles that specifically addressed sleep and CRS were dissected and presented as follows: (1) chronic rhinosinusitis and sleep; (2) chronic rhinosinusitis and fatigue; (3) chronic rhinosinusitis, nasal obstruction, and sleep; and (4) pathophysiology of sleep in chronic rhinosinusitis (cytokines in both sleep and chronic rhinosinusitis and their association to the neuroimmune biology of chronic rhinosinusitis).
Patients with CRS have sleep dysfunction that is associated with their disease severity and overall quality of life. The etiology of sleep dysfunction in CRS is most likely multifactorial. Increasing evidence suggests sleep dysfunction in patients with CRS is partly due to the inflammatory disease process, and sleep physiology in patients with CRS may be actively regulated by the inflammatory component of the disease.