Funding sources for the study: Siemens Corporation and Xoran Technologies (for second scans for study patients); Mayo Clinic Otorhinolaryngology Research Committee (for statistical analyses).
Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: clinical correlations and comparison to Lund-Mackay scoring
Article first published online: 17 SEP 2013
© 2013 ARS-AAOA, LLC
International Forum of Allergy & Rhinology
Volume 3, Issue 12, pages 963–972, December 2013
How to Cite
How to Cite this Article: Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: clinical correlations and comparison to Lund-Mackay scoring. Int Forum Allergy Rhinol. 2013;3:963–972., , , et al.
Potential conflict of interest: L.Y., J.P.: research grant from Xoran Technologies, Inc.; C.H.M., PhD: research support, Siemens Healthcare; A.P.: current employee of Siemens Healthcare.
Presented orally at the ERS-ISIAN Meeting, June 23, 2010, in Geneva, Switzerland.
- Issue published online: 16 DEC 2013
- Article first published online: 17 SEP 2013
- Manuscript Accepted: 1 AUG 2013
- Manuscript Revised: 28 JUN 2013
- Manuscript Received: 14 MAY 2013
- Siemens Corporation and Xoran Technologies
- Mayo Clinic Otorhinolaryngology Research Committee
- computed tomography;
- computer-assisted image analysis;
- quality of life;
We aimed to test the hypothesis that three-dimensional (3D) volume-based scoring of computed tomography (CT) images of the paranasal sinuses was superior to Lund-Mackay CT scoring of disease severity in chronic rhinosinusitis (CRS). We determined correlation between changes in CT scores (using each scoring system) with changes in other measures of disease severity (symptoms, endoscopic scoring, and quality of life) in patients with CRS treated with triamcinolone.
The study group comprised 48 adult subjects with CRS. Baseline symptoms and quality of life were assessed. Endoscopy and CT scans were performed. Patients received a single systemic dose of intramuscular triamcinolone and were reevaluated 1 month later. Strengths of the correlations between changes in CT scores and changes in CRS signs and symptoms and quality of life were determined.
We observed some variability in degree of improvement for the different symptom, endoscopic, and quality-of-life parameters after treatment. Improvement of parameters was significantly correlated with improvement in CT disease score using both CT scoring methods. However, volumetric CT scoring had greater correlation with these parameters than Lund-Mackay scoring.
Volumetric scoring exhibited higher degree of correlation than Lund-Mackay scoring when comparing improvement in CT score with improvement in score for symptoms, endoscopic exam, and quality of life in this group of patients who received beneficial medical treatment for CRS.