Sinonasal alterations in computed tomography scans in cystic fibrosis: a literature review of observational studies

Authors

  • Suzie Hyeona Kang MD,

    Corresponding author
    1. Programa de Pós-Graduação em Ciências Pneumológicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    • Correspondence to: Suzie Hyeona Kang, MD, Rua Ramiro Barcelos, 1245, Apto. 601, Bairro Independência, CEP 90035-006, Porto Alegre, RS, Brazil; e-mail: suziekang82@yahoo.com.br

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  • Otávio Bejzman Piltcher PhD,

    1. Department of Ophthalmology and Otolaryngology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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  • Paulo de Tarso Roth Dalcin PhD

    1. Department of Internal Medicine, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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  • Potential conflict of interest: None provided.

Abstract

Background

Almost all cystic fibrosis (CF) patients reveal upper airway involvement in computed tomography (CT) scans. Sinonasal pathology has become a challenging issue because there are few studies to guide appropriate management. The objective of this study was to provide information about paranasal sinus CT manifestations in CF patients, mainly in adulthood.

Methods

We performed a literature review of descriptive studies about CT sinonasal findings in CF patients using the following databases: MEDLINE, EMBASE, Web of Science, LILACS, Scielo, and Cochrane.

Results

Eighteen articles were included in this review. There was a high variability in methodological aspects for most of the studies. The most prevalent findings reported were opacification of sinuses, presence of frontal and sphenoidal aplasia or hypoplasia, underdevelopment of paranasal sinuses, and medial bulging of the lateral nasal wall in CT scans.

Conclusion

There are few studies in the CF adult population regarding sinonasal CT alterations. Many studies report specific pathological features in CF upper airways that could help in the diagnosis of doubtful cases.

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