Evidence for postjunctional serotonin (5-HT1) receptors in the trigeminocervical complex
Article first published online: 5 NOV 2001
Copyright © 2001 Wiley-Liss, Inc.
Annals of Neurology
Volume 50, Issue 6, pages 804–807, December 2001
How to Cite
Goadsby, P. J., Akerman, S. and Storer, R. J. (2001), Evidence for postjunctional serotonin (5-HT1) receptors in the trigeminocervical complex. Ann Neurol., 50: 804–807. doi: 10.1002/ana.10066
- Issue published online: 29 NOV 2001
- Article first published online: 5 NOV 2001
- Manuscript Revised: 4 SEP 2001
- Manuscript Accepted: 4 SEP 2001
- Manuscript Received: 27 MAR 2001
- The Wellcome Trust
Units linked to stimulation of the superior sagittal sinus were identified and recorded from in the trigeminocervical complex of the anesthetized cat. Iontophoresis of glutamate NMDA receptor agonists increased the baseline-firing rate of these neurons. Coejection of sumatriptan, 4991W93, or ergometrine resulted in a significant reduction in NMDA agonist-induced increases in firing. These data establish the existence of triptan-sensitive (5-HT1) receptors on postsynaptic central trigeminal neurones.