Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset
Article first published online: 31 JAN 2002
Copyright © 2002 Wiley-Liss, Inc.
Annals of Neurology
Volume 51, Issue 2, pages 253–256, February 2002
How to Cite
Bonifati, V., Breedveld, G. J., Squitieri, F., Vanacore, N., Brustenghi, P., Harhangi, B. S., Montagna, P., Cannella, M., Fabbrini, G., Rizzu, P., van Duijn, C. M., Oostra, B. A., Meco, G. and Heutink, P. (2002), Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset. Ann Neurol., 51: 253–256. doi: 10.1002/ana.10106
- Issue published online: 31 JAN 2002
- Article first published online: 31 JAN 2002
- Manuscript Accepted: 31 OCT 2001
- Manuscript Revised: 25 OCT 2001
- Manuscript Received: 16 AUG 2001
- Stichting Klinische Genetica Rotterdam
Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.