Brain white matter anatomy of tumor patients evaluated with diffusion tensor imaging
Article first published online: 27 FEB 2002
Copyright © 2002 Wiley-Liss, Inc.
Annals of Neurology
Volume 51, Issue 3, pages 377–380, March 2002
How to Cite
Mori, S., Frederiksen, K., van Zijl, P. C. M., Stieltjes, B., Kraut, M. A., Solaiyappan, M. and Pomper, M. G. (2002), Brain white matter anatomy of tumor patients evaluated with diffusion tensor imaging. Ann Neurol., 51: 377–380. doi: 10.1002/ana.10137
- Issue published online: 28 FEB 2002
- Article first published online: 27 FEB 2002
- Manuscript Accepted: 4 DEC 2001
- Manuscript Revised: 4 DEC 2001
- Manuscript Received: 15 AUG 2001
- National Institutes of Health (NIH). Grant Number: AG20012
- NIH/National Center for Research (NCRR). Grant Number: RR15241 (to PVZ and SM)
We applied multislice, whole-brain diffusion tensor imaging (DTI) to two patients with anaplastic astrocytoma. Data were analyzed using DTI-based, color-coded images and a 3-D tract reconstruction technique for the study of altered white matter anatomy. Each tumor was near two major white matter tracts, namely, the superior longitudinal fasciculus and the corona radiata. Those tracts were identified using the color-coded maps, and spatial relationships with the tumors were characterized. In one patient the tumor displaced adjacent white matter tracts, whereas in the other it infiltrated the superior longitudinal fasciclus without displacement of white matter. DTI provides new information regarding the detailed relationship between tumor growth and nearby white matter tracts, which may be useful for preoperative planning.