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Loss of interhemispheric inhibition on the ipsilateral primary sensorimotor cortex in patients with brachial plexus injury: fMRI study

Authors

  • Jen-Chuen Hsieh MD, PhD,

    Corresponding author
    1. Integrated Brain Research Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital
    2. Institute of Neuroscience, School of Life Science
    3. Departments of Anesthesiology
    4. Psychiatry
    • Integrated Brain Research Unit, Department of Medical Research and Education, Taipei Veterans General Hospital, No. 201, Sect.2, Shih-Pai Rd., Taipei 112, Taiwan
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  • Henrich Cheng MD, PhD,

    1. Departments of Anesthesiology
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  • Hsiu-Min Hsieh MS,

    1. Integrated Brain Research Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital
    2. Institute of Neuroscience, School of Life Science
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  • Kwong-Kum Liao MD,

    1. Radiology, Faculty of Medicine, School of Medicine
    2. Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Yu-Te Wu PhD,

    1. Integrated Brain Research Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital
    2. Neurology
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  • Tzu-Chen Yeh MD, PhD,

    1. Integrated Brain Research Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital
    2. Radiology, Faculty of Medicine, School of Medicine
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  • Low-Tone Ho MD

    1. Integrated Brain Research Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital
    2. Departments of Anesthesiology
    3. Psychiatry
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Abstract

This functional magnetic resonance imaging study verified an antagonistic pattern in which a concomitant deactivation of ipsilateral primary sensorimotor (SM1) was coupled to the contralateral SM1 activation in healthy controls during unimanual hand grasping. Of note, dramatic reduction of ipsilateral SM1 deactivation (loss of antagonistic pattern) was observed during movement of intact hands by patients with unilateral brachial plexus injury. We propose that the disappearance of the antagonistic pattern of SM1 activities in the patients with brachial plexus injury reflects a reduction of interhemispheric inhibition, which may mirror an adaptive mechanism to functional status.

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