Platelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness
Article first published online: 21 MAY 2002
Copyright © 2002 Wiley-Liss, Inc.
Annals of Neurology
Volume 51, Issue 6, pages 760–763, June 2002
How to Cite
Chang, H.-W., Kwon, S., Kim, H., Lee, K., Kim, M., Moon, T. and Baek, S. (2002), Platelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness. Ann Neurol., 51: 760–763. doi: 10.1002/ana.10168
- Issue published online: 21 MAY 2002
- Article first published online: 21 MAY 2002
- Manuscript Accepted: 16 JAN 2002
- Manuscript Revised: 10 JAN 2002
- Manuscript Received: 27 AUG 2001
Platelet-activating factor acetylhydrolase was analyzed in cerebrospinal fluid samples taken from children with a variety of neurological conditions (85 patients; mean age, 3.8 years) to determine it is involved in the defense mechanism against the toxic effect of inflammatory mediators in the central nervous system. A significant increase in cerebrospinal fluid activity was seen in the patients with meningitis and acute febrile illness in comparison with the control subjects. The activity was also significantly higher in the patients with meningitis than in the patients with inflammatory neurological diseases. In addition, the biochemical profile of cerebrospinal fluid platelet-activating factor acetylhydrolase was different from other known acetylhydrolases. These findings suggest that cerebrospinal fluid platelet-activating factor acetylhydrolase activity may be a sensitive marker of the host response to central nervous system infections.