Brief Communication

Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology

  1. Elisabeth Bergers MD1,*,
  2. Joost C. J. Bot MD1,
  3. Paul van der Valk MD2,
  4. Jonas A. Castelijns MD1,
  5. Geert J. Lycklama A Nijeholt MD1,
  6. Wouter Kamphorst MD2,
  7. Chris H. Polman MD3,
  8. Erwin L. A. Blezer MSc4,
  9. Klaas Nicolay PhD4,
  10. Rivka Ravid PhD4,
  11. Frederik Barkhof MD5

Article first published online: 23 APR 2002

DOI: 10.1002/ana.10170

Issue

Annals of Neurology

Annals of Neurology

Volume 51, Issue 5, pages 652–656, May 2002

Additional Information

How to Cite

Bergers, E., Bot, J. C. J., van der Valk, P., Castelijns, J. A., Lycklama A Nijeholt, G. J., Kamphorst, W., Polman, C. H., Blezer, E. L. A., Nicolay, K., Ravid, R. and Barkhof, F. (2002), Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology. Annals of Neurology, 51: 652–656. doi: 10.1002/ana.10170

Author Information

  1. 1

    Departments of Radiology,

  2. 2

    Pathology, and

  3. 3

    Neurology, VU Medical Center, Amsterdam, The Netherlands

  4. 4

    Image Science Institute, University of Utrecht, Utrecht, The Netherlands

  5. 5

    Netherlands Brain Bank, Amsterdam, The Netherlands

*MS-MRI Centre, Department of Radiology, Academic Hospital, Vrije Universiteit, De Boelelaan 1117, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands

Publication History

  1. Issue published online: 23 APR 2002
  2. Article first published online: 23 APR 2002
  3. Manuscript Accepted: 16 JAN 2002
  4. Manuscript Revised: 10 JAN 2002
  5. Manuscript Received: 21 AUG 2001

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Abstract

In this study, we compared direct postmortem in situ (whole-corpse) sagittal spinal cord magnetic resonance imaging (1.5T) of 7 multiple sclerosis cases with targeted high-resolution in vitro axial magnetic resonance imaging (4.7T) and histopathology. On sagittal in situ magnetic resonance imaging, 1 case had a normal spinal cord, 2 had only focal lesions, 3 had a combination of focal and diffuse abnormalities, and 1 had only diffuse abnormalities. All spinal cords showed abnormalities on high-resolution magnetic resonance imaging and histopathology, confirming the existence of diffuse cord changes as genuine multiple sclerosis-related abnormalities while highlighting the limited resolution of in vivo magnetic resonance imaging.

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