Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy
Version of Record online: 23 APR 2002
Copyright © 2002 Wiley-Liss, Inc.
Annals of Neurology
Volume 51, Issue 5, pages 641–644, May 2002
How to Cite
Briellmann, R. S., Berkovic, S. F., Syngeniotis, A., King, M. A. and Jackson, G. D. (2002), Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy. Ann Neurol., 51: 641–644. doi: 10.1002/ana.10171
- Issue online: 23 APR 2002
- Version of Record online: 23 APR 2002
- Manuscript Accepted: 16 JAN 2002
- Manuscript Revised: 15 JAN 2002
- Manuscript Received: 30 OCT 2001
- National Health and Medical Research Council of Australia
- Brain Imaging Research Foundation in Australia
This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, −30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 ± 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans (p = 0.0007, r = 0.6), suggesting seizure-associated hippocampal damage.