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Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy

Authors

  • Regula S. Briellmann MD,

    1. Brain Research Institute, Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, Australia
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  • Samuel F. Berkovic MD, FRACP,

    1. Brain Research Institute, Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, Australia
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  • Ari Syngeniotis MD,

    1. Brain Research Institute, Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, Australia
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  • Mark A. King FRACP,

    1. Brain Research Institute, Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, Australia
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  • Graeme D. Jackson MD, FRACP

    Corresponding author
    1. Brain Research Institute, Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, Australia
    • Brain Research Institute, Austin and Repatriation Medical Centre, Heidelberg West, Victoria 3084, Australia
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Abstract

This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, −30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 ± 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans (p = 0.0007, r = 0.6), suggesting seizure-associated hippocampal damage.

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