Activity of the hypothalamic–pituitary–adrenal axis in multiple sclerosis: Correlations with gadolinium-enhancing lesions and ventricular volume
Article first published online: 3 MAY 2002
Copyright © 2002 Wiley-Liss, Inc.
Annals of Neurology
Volume 51, Issue 6, pages 763–767, June 2002
How to Cite
Schumann, E. M., Kümpfel, T., Then Bergh, F., Trenkwalder, C., Holsboer, F. and Auer, D. P. (2002), Activity of the hypothalamic–pituitary–adrenal axis in multiple sclerosis: Correlations with gadolinium-enhancing lesions and ventricular volume. Ann Neurol., 51: 763–767. doi: 10.1002/ana.10187
- Issue published online: 21 MAY 2002
- Article first published online: 3 MAY 2002
- Manuscript Accepted: 19 JAN 2002
- Manuscript Revised: 10 JAN 2002
- Manuscript Received: 22 FEB 2001
The known interaction between the immune system and the hypothalamic–pituitary–adrenal axis led us to explore the interrelation between magnetic resonance imaging findings and the hypothalamic–pituitary–adrenal axis activity in 53 multiple sclerosis patients. The cortisol release induced by the dexamethasone-corticotropin-releasing hormone test was negatively associated with the presence and number of gadolinium-enhancing lesions and positively associated with ventricular size. This finding suggests a protective effect of the hypothalamic– pituitary–adrenal drive on acute lesional inflammation in multiple sclerosis, probably by limiting immune overshoot. In contrast, the nature of the correlation between hypothalamic–pituitary–adrenal hyperdrive and brain atrophy remains to be determined.