Focal cooling rapidly terminates experimental neocortical seizures
Version of Record online: 2 APR 2001
Copyright © 2001 Wiley-Liss, Inc.
Annals of Neurology
Volume 49, Issue 6, pages 721–726, June 2001
How to Cite
Yang, X.-F. and Rothman, S. M. (2001), Focal cooling rapidly terminates experimental neocortical seizures. Ann Neurol., 49: 721–726. doi: 10.1002/ana.1021
- Issue online: 5 JUN 2001
- Version of Record online: 2 APR 2001
- Manuscript Accepted: 5 DEC 2000
- Manuscript Revised: 16 NOV 2000
- Manuscript Received: 28 SEP 2000
- NIH. Grant Number: NS14834
- Stein Fund for Pediatric Neurology Research
The efficacy of surgical resection for epilepsy is considerably lower for neocortical epilepsy than for temporal lobe epilepsy. We have explored focal cooling with a thermoelectric (Peltier) device as a potential therapy for neocortical epilepsy. After creating a cranial window in anesthetized rats, we induced seizures by injecting artificial cerebrospinal fluid containing 4-aminopyridine (4-AP), a potassium channel blocker. Within 30 minutes of 4-AP injection, animals developed recurrent seizures (duration 85.7 ± 26.2 seconds; n = 10 rats) that persisted for 2 hours. When a small Peltier device cooled the exposed cortical surface to 20–25°C at seizure onset, the seizure duration was reduced to 8.4 ± 5.0 seconds (n = 10 rats; p < 0.001). When the Peltier device was placed close to the cortical surface, but not allowed to make physical contact, there was no effect on seizure duration (104.3 ± 20.7 seconds; p > 0.05 compared to control). Interestingly, the duration of uncooled seizures was reduced after we allowed the cortex to rewarm from prior cooling. Histological examination of the cortex after cooling has shown no evidence of acute or delayed neuronal injury, and blood pressure and temperature remained stable. It may be possible to use Peltier devices for cortical mapping or, when seizure detection algorithms improve, for chronic seizure control.