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Abstract

Intracytoplasmic inclusions composed of α-synuclein (α-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered α-syn, we uncovered an unprecedented and extensive burden of α-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these α-syn aggregates may contribute to the parkinsonism seen in these disorders.