Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

Authors

  • John E. Duda MD,

    1. Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine
    2. Parkinson's Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Hospital, Philadelphia, PA
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  • Benoit I. Giasson PhD,

    1. Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine
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  • Meghann E. Mabon BA,

    1. Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine
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  • Virginia M.-Y. Lee PhD,

    1. Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine
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  • John Q. Trojanowski MD, PhD

    Corresponding author
    1. Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine
    • Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, Philadelphia, PA 19104
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Abstract

Intracytoplasmic inclusions composed of α-synuclein (α-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered α-syn, we uncovered an unprecedented and extensive burden of α-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these α-syn aggregates may contribute to the parkinsonism seen in these disorders.

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