This article is a US Government work and, as such, is in the public domain in the United States of America.
Age-dependent changes in the ability to encode a novel elementary motor memory†
Article first published online: 24 MAR 2003
Published 2003 Wiley-Liss, Inc.
Annals of Neurology
Volume 53, Issue 4, pages 521–524, April 2003
How to Cite
Sawaki, L., Yaseen, Z., Kopylev, L. and Cohen, L. G. (2003), Age-dependent changes in the ability to encode a novel elementary motor memory. Ann Neurol., 53: 521–524. doi: 10.1002/ana.10529
- Issue published online: 24 MAR 2003
- Article first published online: 24 MAR 2003
- Manuscript Revised: 9 DEC 2002
- Manuscript Accepted: 9 DEC 2002
- Manuscript Received: 15 JUL 2002
- National Center for Complementary and Alternative Medicine/National Institutes of Health
In healthy individuals, motor training elicits cortical plasticity that encodes the kinematic details of the practiced movements and is thought to underlie recovery of function after stroke. The influence of age on this form of plasticity is incompletely understood. We studied 55 healthy subjects and identified a substantial decrease in training-dependent plasticity as a function of age in the absence of differences in training kinematics. These results suggest that the ability of the healthy aging motor cortex to reorganize in response to training decreases with age. Ann Neurol 2003;53:521–524