Get access

Age-dependent changes in the ability to encode a novel elementary motor memory

Authors

  • Lumy Sawaki MD, PhD,

    1. Human Cortical Physiology Section/National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
    Search for more papers by this author
  • Zaneb Yaseen BS,

    1. Human Cortical Physiology Section/National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
    Search for more papers by this author
  • Leonid Kopylev PhD,

    1. Biostatistics Branch/National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
    Search for more papers by this author
  • Leonardo G. Cohen MD

    Corresponding author
    1. Human Cortical Physiology Section/National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
    • Building 10, Room 5N 226, National Institutes of Health, 10 Center Drive, MSC 1428, Bethesda, MD 20892-1428
    Search for more papers by this author

  • This article is a US Government work and, as such, is in the public domain in the United States of America.

Abstract

In healthy individuals, motor training elicits cortical plasticity that encodes the kinematic details of the practiced movements and is thought to underlie recovery of function after stroke. The influence of age on this form of plasticity is incompletely understood. We studied 55 healthy subjects and identified a substantial decrease in training-dependent plasticity as a function of age in the absence of differences in training kinematics. These results suggest that the ability of the healthy aging motor cortex to reorganize in response to training decreases with age. Ann Neurol 2003;53:521–524

Get access to the full text of this article

Ancillary