A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions
Article first published online: 27 APR 2001
Copyright © 2001 Wiley-Liss, Inc.
Annals of Neurology
Volume 49, Issue 6, pages 793–796, June 2001
How to Cite
Bitsch, A., Kuhlmann, T., Stadelmann, C., Lassmann, H., Lucchinetti, C. and Brück, W. (2001), A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions. Ann Neurol., 49: 793–796. doi: 10.1002/ana.1053
- Issue published online: 5 JUN 2001
- Article first published online: 27 APR 2001
- Manuscript Accepted: 17 FEB 2001
- Manuscript Revised: 16 FEB 2001
- Manuscript Received: 20 NOV 2000
- Gemeinnützige Hertie-Stiftung. Grant Number: 2/540/99
- United States Multiple Sclerosis Society. Grant Number: RG 3051-A-1
Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsied MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time.