Get access

Weight loss in Parkinson's disease

Authors

  • Honglei Chen MD, PhD,

    Corresponding author
    1. Departments of Nutrition, Harvard School of Public Health
    • Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
    Search for more papers by this author
  • Shumin M. Zhang MD, ScD,

    1. Departments of Epidemiology, Harvard School of Public Health
    2. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    Search for more papers by this author
  • Miguel A. Hernán MD, DrPH,

    1. Departments of Epidemiology, Harvard School of Public Health
    Search for more papers by this author
  • Walter C. Willett MD, DrPH,

    1. Departments of Nutrition, Harvard School of Public Health
    2. Departments of Epidemiology, Harvard School of Public Health
    3. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    Search for more papers by this author
  • Alberto Ascherio MD, DrPH

    1. Departments of Nutrition, Harvard School of Public Health
    2. Departments of Epidemiology, Harvard School of Public Health
    3. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    Search for more papers by this author

Abstract

We prospectively examined the changes of body weight among 468 individuals with Parkinson's disease (PD) before and after the diagnosis. The average weight of PD patients was stable until shortly before the diagnosis (p for trend = 0.2) and then declined (p for trend < 0.0001). Interestingly, PD patients tended to increase their energy intakes as their weights decreased (p for trend < 0.002). In conclusion, weight loss in PD patients appears to be a continuous process that starts several years before the diagnosis and is not caused by reduced energy intake. Ann Neurol 2003;53:676–679

Ancillary