Autoantibodies to amyloid-β and Alzheimer's disease

Authors

  • Bradley T. Hyman MD PhD,

    Corresponding author
    1. Alzheimer Disease Research Unit, Massachusetts General Hospital, Charlestown, MA
    • Department of Neurology, Harvard Medical School, Alzheimer Research Unit, Massachusetts General Hospital, 114 16th St, Rm 2009, Charlestown, MA 02129
    Search for more papers by this author
  • Carolyn Smith MA,

    1. Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    2. Department of Psychiatry, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    Search for more papers by this author
  • Ilya Buldyrev,

    1. Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    2. Department of Psychiatry, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    Search for more papers by this author
  • Christa Whelan BS,

    1. Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    2. Department of Psychiatry, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    Search for more papers by this author
  • Harold Brown MD,

    1. Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    2. Department of Psychiatry, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    Search for more papers by this author
  • Ming-Xin Tang PhD,

    1. Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    2. Department of Psychiatry, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    Search for more papers by this author
  • Richard Mayeux MD MSc

    1. Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    2. Department of Psychiatry, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY
    Search for more papers by this author

Abstract

Immunization against amyloid-β has been suggested as a possible preventive or therapeutic treatment for Alzheimer's disease. We hypothesized that some individuals may have autoantibodies to amyloid-β and that this may be protective. We analyzed the plasma of 365 individuals, drawn from a larger longitudinal epidemiological study, for the presence of antibodies to amyloid-β. There were detectable but very low levels of anti-amyloid-β antibodies in just over 50% of all samples and modest levels in under 5% of all samples. However, neither the presence nor the level of anti-amyloid-β antibodies correlated with the likelihood of developing dementia or with plasma levels of amyloid-β peptide. These data suggest that low levels of anti-amyloid-β autoantibodies are frequent in the elderly population but do not confer protection against developing dementia.

Ancillary