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Articles
The lumbar puncture for diagnosis of pediatric neurotransmitter diseases
Article first published online: 25 JUL 2003
DOI: 10.1002/ana.10627
Copyright © 2003 American Neurological Association
Issue
1531-8249/asset/cover.gif?v=1&s=685ec69724c5ed4c8847ce939e70ceb45065856f "Annals of Neurology")
Annals of Neurology
Supplement: Pediatric Neurotransmitter Diseases
Volume 54, Issue Supplement 6, pages S13–S17, 2003
Additional Information
How to Cite
Hyland, K. (2003), The lumbar puncture for diagnosis of pediatric neurotransmitter diseases. Ann Neurol., 54: S13–S17. doi: 10.1002/ana.10627
Publication History
- Issue published online: 25 JUL 2003
- Article first published online: 25 JUL 2003
- Abstract
- Article
- References
- Cited By
Abstract
The investigation of infants and children with suspected pediatric neurotransmitter diseases affecting serotonin and catecholamine metabolism is complicated because the measurement of metabolites in peripheral fluids is generally uninformative. Disorders that affect catecholamine (dopamine and norepinephrine) and serotonin neurotransmission, and that do not present with hyperphenylalaninemia, require that a lumbar puncture be performed and that specific metabolites be assessed in the collected cerebrospinal fluid. This review will discuss the disorders affecting catecholamine and serotonin biosynthesis, sample collection and handling, diagnostic methods and expected profiles, problems with diagnosis, and as yet to be described conditions that might be detected using current diagnostic methodologies. Ann Neurol 2003;54 (suppl 6):S13–S17