Articles

Transgenic mouse models of dopamine deficiency

  1. Linan Chen PhD,
  2. Xiaoxi Zhuang PhD*

Article first published online: 25 JUL 2003

DOI: 10.1002/ana.10655

Issue

Annals of Neurology

Annals of Neurology

Supplement: Pediatric Neurotransmitter Diseases

Volume 54, Issue Supplement 6, pages S91–S102, 2003

Additional Information

How to Cite

Chen, L. and Zhuang, X. (2003), Transgenic mouse models of dopamine deficiency. Ann Neurol., 54: S91–S102. doi: 10.1002/ana.10655

Author Information

  1. Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, IL

*Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, 924 East 57th Street, Knapp Center, R214, Chicago, IL 60637

Publication History

  1. Issue published online: 25 JUL 2003
  2. Article first published online: 25 JUL 2003

Funded by

  • National Alliance for Research on Schizophrenia and Depression
  • National Parkinson Foundation
  • Tourette Syndrome Association

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Abstract

The dopamine system is implicated in several neurological and psychiatric disorders. Genetic mutations or variations that affect dopamine system functions either directly cause or contribute to these disorders, even though other genetic and environmental factors may contribute significantly to some of these disorders as well. Transgenic mice increasingly become important tools in revealing functions of genes that are essential components of the dopamine system as well as in modeling human genetic disorders. We have reviewed a comprehensive list of those genes and compared genetic mutations/variations in humans and transgenic mouse models. The significance and limitations of these animal models as well as future directions are discussed. Ann Neurol 2003;54 (suppl 6):S91–S102

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