Levodopa induces dyskinesias in normal squirrel monkeys
Article first published online: 28 JUN 2001
Copyright © 2001 Wiley-Liss, Inc.
Annals of Neurology
Volume 50, Issue 2, pages 254–257, August 2001
How to Cite
Togasaki, D. M., Tan, L., Protell, P., Di Monte, D. A., Quik, M. and Langston, J. W. (2001), Levodopa induces dyskinesias in normal squirrel monkeys. Ann Neurol., 50: 254–257. doi: 10.1002/ana.1099
- Issue published online: 30 JUL 2001
- Article first published online: 28 JUN 2001
- Manuscript Accepted: 4 MAY 2001
- Manuscript Revised: 23 APR 2001
- Manuscript Received: 11 DEC 2000
- National Institutes of Health. Grant Number: NS34886-01A2
- National Parkinson's Foundation
- National Medical Research Council-Singapore
This study assessed whether or not levodopa induces dyskinesias in normal (ie, unlesioned) squirrel monkeys. All six animals treated twice daily with levodopa (15 mg/kg with carbidopa by oral gavage) for two weeks developed choreoathetoid dyskinesias, whereas none of the vehicle-treated animals displayed any abnormal movements. These dyskinesias did not merely reflect a generalized motor activation as locomotion was actually suppressed. The present data demonstrate that preexisting nigrostriatal damage is not necessary for the development of levodopa-induced dyskinesias.