Proton magnetic resonance spectroscopy of brain metabolites in galactosemia
Article first published online: 3 JUL 2001
Copyright © 2001 Wiley-Liss, Inc.
Annals of Neurology
Volume 50, Issue 2, pages 266–269, August 2001
How to Cite
Wang, Z. J., Berry, G. T., Dreha, S. F., Zhao, H., Segal, S. and Zimmerman, R. A. (2001), Proton magnetic resonance spectroscopy of brain metabolites in galactosemia. Ann Neurol., 50: 266–269. doi: 10.1002/ana.1102
- Issue published online: 30 JUL 2001
- Article first published online: 3 JUL 2001
- Manuscript Accepted: 17 MAY 2001
- Manuscript Revised: 15 MAY 2001
- Manuscript Received: 29 MAR 2001
- National Institutes of Health. Grant Number: HDPO1-29847
- German Scholarship Foundation
Brain edema may occur in infants with galactosemia and has been associated with accumulation of galactitol. Proton magnetic resonance spectra were obtained from 12 patients (four newly diagnosed neonates and eight patients on galactose-restricted diets, age range 1.7–47 years) and control subjects to measure brain galactitol levels in vivo and correlate them with urinary galactitol excretion. The results demonstrate that a markedly elevated brain galactitol level may be present only in newborn infants with galactosemia who exhibit massive urinary galactitol excretion.