Elevated corticotropin releasing hormone/corticotropin releasing hormone-R1 expression in postmortem brain obtained from children with generalized epilepsy

Authors

  • Wei Wang MD,

    1. Department of Paediatrics, Kingston General Hospital, Kingston, Ontario, Canada
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  • Kimberly E. Dow MD,

    1. Department of Paediatrics, Kingston General Hospital, Kingston, Ontario, Canada
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  • Douglas D. Fraser MD, PhD

    Corresponding author
    1. Department of Paediatrics, Kingston General Hospital, Kingston, Ontario, Canada
    2. Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada
    3. Clinical Trials Group, Canadian Paediatric Epilepsy Network (CPEN), Canada
    • Department of Pediatrics, Division of Critical Care Medicine, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
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Abstract

The corticotropin releasing hormone (CRH) system has been suggested to initiate seizure activity in the developing brain. However, human data to support this theory is lacking. In this study, we have demonstrated that the expression of CRH, CRH-binding protein, and CRH-R1 (a CRH membrane receptor) were significantly elevated in cortical tissue obtained from 6 children with generalized epilepsy (mean age 8.2 ± 1.5 years) relative to age-matched controls (mean age 7.8 ± 1.4 years). In contrast, no significant difference in the expression of CRH-R2 was observed. The advent of CRH-R1 receptor antagonists may prove useful as novel anticonvulsants.

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