Dextran reduces embolic signals after carotid endarterectomy
Article first published online: 8 OCT 2001
Copyright © 2001 Wiley-Liss, Inc.
Annals of Neurology
Volume 50, Issue 4, pages 544–547, October 2001
How to Cite
Levi, C. R., Stork, J. L., Chambers, B. R., Abbott, A. L., Cameron, H. M., Peeters, A., Royle, J. P., Roberts, A. K., Fell, G., Hoare, M. C., Chan, A. T. W. and Donnan, G. A. (2001), Dextran reduces embolic signals after carotid endarterectomy. Ann Neurol., 50: 544–547. doi: 10.1002/ana.1233
- Issue published online: 8 OCT 2001
- Article first published online: 8 OCT 2001
- Manuscript Accepted: 29 JUN 2001
- Manuscript Received: 9 FEB 2001
One hundred fifty patients undergoing carotid endarterectomy were randomly assigned to receive intravenous 10% dextran 40 or placebo. Transcranial Doppler monitoring of the ipsilateral middle cerebral artery 0 to 1 hour postoperatively detected embolic signals in 57% of placebo and 42% of dextran patients, with overall embolic signal counts 46% less for dextran (p = 0.052). Two to 3 hours postoperatively, embolic signals were present in 45% of placebo and 27% of dextran patients, with embolic signal counts 64% less for dextran (p = 0.040). We conclude that dextran reduces embolic signals within 3 hours of CEA.