Original Articles

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

  1. William E. Klunk MD, PhD1,
  2. Henry Engler MD2,
  3. Agneta Nordberg MD, PhD3,4,
  4. Yanming Wang PhD5,
  5. Gunnar Blomqvist PhD2,
  6. Daniel P. Holt BS5,
  7. Mats Bergström PhD2,
  8. Irina Savitcheva MD2,
  9. Guo-Feng Huang PhD5,
  10. Sergio Estrada PhD2,
  11. Birgitta Ausén MSCI4,
  12. Manik L. Debnath MS1,
  13. Julien Barletta BS6,
  14. Julie C. Price PhD5,
  15. Johan Sandell PhD2,
  16. Brian J. Lopresti BS5,
  17. Anders Wall PhD2,
  18. Pernilla Koivisto PhD2,
  19. Gunnar Antoni PhD2,
  20. Chester A. Mathis PhD5,*,
  21. Bengt Långström PhD2,6

Article first published online: 21 JAN 2004

DOI: 10.1002/ana.20009

Issue

Annals of Neurology

Annals of Neurology

Volume 55, Issue 3, pages 306–319, March 2004

Additional Information

How to Cite

Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G.-F., Estrada, S., Ausén, B., Debnath, M. L., Barletta, J., Price, J. C., Sandell, J., Lopresti, B. J., Wall, A., Koivisto, P., Antoni, G., Mathis, C. A. and Långström, B. (2004), Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Annals of Neurology, 55: 306–319. doi: 10.1002/ana.20009

Author Information

  1. 1

    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA

  2. 2

    Uppsala University, PET Centre/Uppsala Imanet AB, Uppsala

  3. 3

    Neurotec Department, Karolinska Institute, Huddinge University Hospital, Stockholm

  4. 4

    Department of Geriatric Medicine, Huddinge University Hospital, Stockholm, Sweden

  5. 5

    Department of Radiology, PET Facility, University of Pittsburgh, Pittsburgh, PA

  6. 6

    Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

*PET Facility, B-938 UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213-2582

Publication History

  1. Issue published online: 20 FEB 2004
  2. Article first published online: 21 JAN 2004
  3. Manuscript Accepted: 18 NOV 2003
  4. Manuscript Revised: 4 NOV 2003
  5. Manuscript Received: 9 SEP 2003

Funded by

  • Alzheimer's Association. Grant Numbers: IIRG-95-076, TLL-01-3381, NIRG-00-2335
  • National Institute of Aging. Grant Numbers: AG01039, AG20226, AG18402
  • Institute for the Study of Aging/American Federation for Aging Research
  • Swedish Medical Research Council. Grant Number: 05817
  • Stohnes Foundation
  • University of Pittsburgh Alzheimer Disease Research Center Brain Bank. Grant Number: AG05133

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Abstract

This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 ± 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = −0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.

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