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Original Articles
Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
Article first published online: 23 FEB 2004
DOI: 10.1002/ana.20016
Copyright © 2003 American Neurological Association
1531-8249/asset/cover.gif?v=1&s=685ec69724c5ed4c8847ce939e70ceb45065856f "Annals of Neurology")
Additional Information
How to Cite
Barnett, M. H. and Prineas, J. W. (2004), Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion. Annals of Neurology, 55: 458–468. doi: 10.1002/ana.20016
Publication History
- Issue published online: 21 MAR 2004
- Article first published online: 23 FEB 2004
- Manuscript Revised: 25 NOV 2003
- Manuscript Accepted: 25 NOV 2003
- Manuscript Received: 30 JUN 2003
Funded by
- National Health and Medical Research Council of Australia scholarship
- Australian Association of Neurologists/Novartis fellowship
- Nerve Research Foundation (University of Sydney)
- National Multiple Sclerosis Society (United States). Grant Number: RG 2731-A-8
Abstract
The study describes the clinical and pathological findings in 12 patients with relapsing and remitting multiple sclerosis, who died during or shortly after the onset of a relapse. Pathological changes not previously associated with the formation of new symptomatic lesions were observed in seven cases, namely, extensive oligodendrocyte apoptosis and microglial activation in myelinated tissue containing few or no lymphocytes or myelin phagocytes. No current laboratory model of multiple sclerosis, in particular, experimental allergic encephalomyelitis, is known with these features, which raises the possibility of some novel process underlying new lesion formation in multiple sclerosis. Ann Neurol 2004;55:000–000