Brief Communication

Molecular epidemiology of spinocerebellar ataxia type 6

  1. Kate Craig BSc(Hons)1,
  2. Sharon M. Keers BSc(Hons)1,
  3. Kate Archibald BSc(Hons)2,
  4. Ann Curtis BSc(Hons)2,
  5. Patrick F. Chinnery PhD, MRCF1,2,*

Article first published online: 26 APR 2004

DOI: 10.1002/ana.20110

Issue

Annals of Neurology

Annals of Neurology

Volume 55, Issue 5, pages 752–755, May 2004

Additional Information

How to Cite

Craig, K., Keers, S. M., Archibald, K., Curtis, A. and Chinnery, P. F. (2004), Molecular epidemiology of spinocerebellar ataxia type 6. Ann Neurol., 55: 752–755. doi: 10.1002/ana.20110

Author Information

  1. 1

    Neurology, University Newcastle upon Tyne, United Kingdom

  2. 2

    Institute of Human Genetics, University Newcastle upon Tyne, United Kingdom

*Neurology, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom

Publication History

  1. Issue published online: 26 APR 2004
  2. Article first published online: 26 APR 2004
  3. Manuscript Accepted: 15 MAR 2004
  4. Manuscript Revised: 11 MAR 2004
  5. Manuscript Received: 15 DEC 2003

Funded by

  • Ataxia UK. Grant Number: 071095/Z/03/Z

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (246K)

Abstract

We performed a population-based clinical and molecular genetic study of spinocerebellar ataxia type 6 (SCA6) in the northeast of England. The minimum point prevalence of SCA6 was 1.59 in 100,000 (95% confidence interval [CI], 1.04–2.14), and the number of individuals who either had SCA6 or are at risk of developing SCA6 was at least 5.21 in 100,000 (95% CI, 4.31–6.10), or 1 in 19,210. Microsatellite analysis of the CACNA1A gene indicated a founder effect for SCA6 within this region.

View Full Article (HTML) Get PDF (246K)