Brief Communication

Changes in brain anatomy in focal hand dystonia

  1. Gaëtan Garraux MD, PhD1,2,
  2. Andrew Bauer1,
  3. Takashi Hanakawa MD, PhD1,
  4. Tao Wu MD1,
  5. Kenji Kansaku MD, PhD1,
  6. Mark Hallett MD1,*

Article first published online: 26 APR 2004

DOI: 10.1002/ana.20113

Issue

Annals of Neurology

Annals of Neurology

Volume 55, Issue 5, pages 736–739, May 2004

Additional Information

How to Cite

Garraux, G., Bauer, A., Hanakawa, T., Wu, T., Kansaku, K. and Hallett, M. (2004), Changes in brain anatomy in focal hand dystonia. Ann Neurol., 55: 736–739. doi: 10.1002/ana.20113

Author Information

  1. 1

    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD

  2. 2

    Cyclotron Research Center and Department of Neurology, University of Liège, Sart Tilman, Liège, Belgium

*Human Motor Control Section, NINDS, NIH, Building 10, Room 5N226, 10 Center Drive, MSC 1428, Bethesda, MD 20892-1428

Publication History

  1. Issue published online: 26 APR 2004
  2. Article first published online: 26 APR 2004
  3. Manuscript Accepted: 4 MAR 2004
  4. Manuscript Revised: 3 MAR 2004
  5. Manuscript Received: 7 OCT 2003

Funded by

  • Horlais-Daspens Foundation
  • Belgian American Educational Foundation
  • North Atlantic Treaty Organization (NATO)
  • NIH (National Institute of Neurological Disorders and Stroke

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Abstract

No consistent cerebral anatomical abnormality has ever been reported in primary focal hand dystonia (FHD). The present voxel-based morphometry study showed a significant bilateral increase in gray matter in the hand representation area of primary somatosensory and, to a lesser extent, primary motor cortices in 36 patients with unilateral FHD compared with 36 controls. The presence of anatomical changes in the perirolandic cortex for the unaffected hand as well as that for the affected hand suggests that these disturbances may be, at least in part, primary.

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