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Brief Communication

α-Synuclein promoter confers susceptibility to Parkinson's disease

  1. Philippe Pals MD1,2,
  2. Sarah Lincoln BSc3,
  3. Jonathan Manning BSc3,
  4. Michael Heckman MS3,
  5. Lisa Skipper MSc3,
  6. Mary Hulihan MPH3,
  7. Marleen Van den Broeck1,
  8. Tim De Pooter1,
  9. Patrick Cras MD2,
  10. Julia Crook PhD3,
  11. Christine Van Broeckhoven PhD1,
  12. Matt J. Farrer PhD3,*

Article first published online: 28 SEP 2004

DOI: 10.1002/ana.20268

Issue

Annals of Neurology

Annals of Neurology

Volume 56, Issue 4, pages 591–595, October 2004

Additional Information

How to Cite

Pals, P., Lincoln, S., Manning, J., Heckman, M., Skipper, L., Hulihan, M., Van den Broeck, M., De Pooter, T., Cras, P., Crook, J., Van Broeckhoven, C. and Farrer, M. J. (2004), α-Synuclein promoter confers susceptibility to Parkinson's disease. Ann Neurol., 56: 591–595. doi: 10.1002/ana.20268

Author Information

  1. 1

    Department of Molecular Genetics VIB8, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium

  2. 2

    Born Bunge Foundation, University of Antwerp and Division of Neurology, University Hospital Antwerp, Belgium

  3. 3

    Department of Neuroscience, Mayo Clinic Jacksonville and Rochester, Mayo Clinic, Jacksonville, FL

*Department of Neuroscience, Mayo Clinic Jacksonville and Rochester, Mayo Clinic Jacksonville, 4500 San Pablo Rd., Jacksonville, FL 32224

Publication History

  1. Issue published online: 28 SEP 2004
  2. Article first published online: 28 SEP 2004
  3. Manuscript Revised: 15 JUL 2004
  4. Manuscript Accepted: 15 JUL 2004
  5. Manuscript Received: 14 MAY 2004

Funded by

  • Fund for Scientific Research, Flanders, Belgium, a research project of the University Hospital Antwerp
  • Genetic Service Facility () [http://www.vibgeneticservicefacility.be]
  • The Michael J. Fox Foundation

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Abstract

Familial Parkinson's disease (PD) has been linked to missense and genomic multiplication mutations of the α-synuclein gene (SNCA). Genetic variability within SNCA has been implicated in idiopathic PD in many populations. We now confirm and extend these findings, within a Belgian sample, using a high-resolution map of genetic markers across the SNCA locus. Our study implicates the SNCA promoter in susceptibility to PD, and more specifically defines a minimum promoter haplotype, spanning approximately 15.3kb of sequence, which is overrepresented in patients. Our findings represent a biomarker for PD and may have implications for patient diagnosis, longitudinal evaluation, and treatment. Ann Neurol 2004;56:591–595

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