Brief Communication

Serum lipids and hippocampal volume: The link to Alzheimer's disease?

  1. Henrike Wolf MD, PhD1,2,*,
  2. Anke Hensel DP1,
  3. Thomas Arendt MD, PhD3,
  4. Miia Kivipelto MD, PhD2,
  5. Bengt Winblad MD, PhD2,
  6. Hermann-Josef Gertz MD, PhD1

Article first published online: 25 OCT 2004

DOI: 10.1002/ana.20289

Issue

Annals of Neurology

Annals of Neurology

Volume 56, Issue 5, pages 745–749, November 2004

Additional Information

How to Cite

Wolf, H., Hensel, A., Arendt, T., Kivipelto, M., Winblad, B. and Gertz, H.-J. (2004), Serum lipids and hippocampal volume: The link to Alzheimer's disease?. Annals of Neurology, 56: 745–749. doi: 10.1002/ana.20289

Author Information

  1. 1

    Department of Psychiatry, University of Leipzig, Leipzig, Germany

  2. 2

    Department of Neurotec, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden

  3. 3

    Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany

*Karolinska Institutet, Department of Neurotec, Division of Clinical Geriatrics/Aging Research Center, Olivecronas v. 4, Box 6401, S- 11382 Stockholm, Sweden

Publication History

  1. Issue published online: 25 OCT 2004
  2. Article first published online: 25 OCT 2004
  3. Manuscript Accepted: 10 AUG 2004
  4. Manuscript Revised: 23 JUL 2004
  5. Manuscript Received: 26 APR 2004

Funded by

  • Interdisziplinäres Zentrum für Klinische Forschung, Projekt C8, (Department of Psychiatry, University of Leipzig
  • Deutsche Forschungsgemeinschaft
  • Gunoch Bertil Stohne Stiftelse

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Abstract

The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was studied in 86 elderly subjects with a range of cognitive functions. High-density lipoprotein cholesterol, but not low-density lipoprotein cholesterol or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of high-density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease. Ann Neurol 2004;56:745–749

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