Brief Communication

Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD

  1. Angela Pyle PhD1,
  2. Thomas Foltynie PhD, MRCP2,
  3. Watcharee Tiangyou BSc1,
  4. Claire Lambert BSc1,
  5. Sharon M. Keers BSc1,
  6. Liesl M. Allcock MRCP3,
  7. Jill Davison BSc3,
  8. Simon J. Lewis MRCP2,
  9. Robert H. Perry FRCP4,
  10. Roger Barker FRCP2,
  11. David J. Burn MD, FRCP3,4,5,
  12. Patrick F. Chinnery PhD, MRCP1,5,*

Article first published online: 22 MAR 2005

DOI: 10.1002/ana.20417

Issue

Annals of Neurology

Annals of Neurology

Volume 57, Issue 4, pages 564–567, April 2005

Additional Information

How to Cite

Pyle, A., Foltynie, T., Tiangyou, W., Lambert, C., Keers, S. M., Allcock, L. M., Davison, J., Lewis, S. J., Perry, R. H., Barker, R., Burn, D. J. and Chinnery, P. F. (2005), Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD. Ann Neurol., 57: 564–567. doi: 10.1002/ana.20417

Author Information

  1. 1

    Mitochondrial Research Group, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom

  2. 2

    Cambridge Centre for Brain Repair, The University of Cambridge, Cambridge, United Kingdom

  3. 3

    Department of Neurology, Sunderland Royal Hospital, Sunderland, United Kingdom

  4. 4

    Institute of Ageing and Health, University of Newcastle upon Tyne, United Kingdom

  5. 5

    Department of Neurology, Regional Neurosciences Centre, Newcastle upon Tyne, United Kingdom

*Neurology, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK

Publication History

  1. Issue published online: 22 MAR 2005
  2. Article first published online: 22 MAR 2005
  3. Manuscript Revised: 18 JAN 2005
  4. Manuscript Accepted: 18 JAN 2005
  5. Manuscript Received: 24 SEP 2004

Funded by

  • Wellcome Trust. Grant Numbers: Senior Fellowship in Clinical Science 071095/Z/03/2, Ataxia UK GR065473MA
  • Alzheimer's Research Trust
  • Association Francaise contre les Myopathies
  • Rhoda Lockhart Parkinson's Disease Research Fund, University of Newcastle upon Tyne

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Abstract

There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or the UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases. Ann Neurol 2005;57:564–567

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