Amyloid β 38, 40, and 42 species in cerebrospinal fluid: More of the same?

Authors

  • Niki S. Schoonenboom MD,

    Corresponding author
    1. Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands
    2. Department of Clinical Chemistry, VU University Medical Center, Amsterdam, the Netherlands
    • Departments of Neurology and Clinical Chemistry, VU University Medical Center, P.O. Box 7057, 1081 HV Amsterdam, the Netherlands
    Search for more papers by this author
  • Cees Mulder MSc,

    1. Department of Clinical Chemistry, VU University Medical Center, Amsterdam, the Netherlands
    Search for more papers by this author
  • Gerard J. Van Kamp PhD,

    1. Department of Clinical Chemistry, VU University Medical Center, Amsterdam, the Netherlands
    Search for more papers by this author
  • Sangita P. Mehta MSc,

    1. Department of Developmental Neurobiology, Division of Immunology, Institute for Basic Research in Developmental Disabilities, Staten Island, NY
    Search for more papers by this author
  • Philip Scheltens MD, PhD,

    1. Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands
    Search for more papers by this author
  • Marinus A. Blankenstein PhD,

    1. Department of Clinical Chemistry, VU University Medical Center, Amsterdam, the Netherlands
    Search for more papers by this author
  • Pankaj D. Mehta PhD

    1. Department of Developmental Neurobiology, Division of Immunology, Institute for Basic Research in Developmental Disabilities, Staten Island, NY
    Search for more papers by this author

Abstract

Various C-terminally truncated amyloid β peptides (Aβ) are linked to Alzheimer's disease (AD) pathogenesis. Cerebrospinal fluid (CSF) concentrations of Aβ38, Aβ40, and Aβ42 were measured by enzyme-linked immunosorbent assay in 30 patients with AD and 26 control subjects. CSF Aβ42 levels was decreased in patients with AD, whereas CSF Aβ38 and Aβ40 levels were similar in patients with AD and control subjects. All three Aβ peptides were interrelated, particularly CSF Aβ38 and Aβ40. Diagnostic accuracy of CSF Aβ42 concentrations was not improved by applying the ratios of CSF Aβ42 to Aβ38 or Aβ40. Ann Neurol 2005;58:139–142

Ancillary