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Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

  1. Chris H. Polman MD, PhD1,*,
  2. Stephen C. Reingold PhD2,
  3. Gilles Edan MD3,
  4. Massimo Filippi MD4,
  5. Hans-Peter Hartung MD5,
  6. Ludwig Kappos MD6,
  7. Fred D. Lublin MD7,
  8. Luanne M. Metz MD8,
  9. Henry F. McFarland MD9,
  10. Paul W. O'Connor MD10,
  11. Magnhild Sandberg-Wollheim MD11,
  12. Alan J. Thompson MD12,
  13. Brian G. Weinshenker MD13,
  14. Jerry S. Wolinsky MD14

Article first published online: 10 NOV 2005

DOI: 10.1002/ana.20703

Issue

Annals of Neurology

Annals of Neurology

Volume 58, Issue 6, pages 840–846, December 2005

Additional Information

How to Cite

Polman, C. H., Reingold, S. C., Edan, G., Filippi, M., Hartung, H.-P., Kappos, L., Lublin, F. D., Metz, L. M., McFarland, H. F., O'Connor, P. W., Sandberg-Wollheim, M., Thompson, A. J., Weinshenker, B. G. and Wolinsky, J. S. (2005), Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Annals of Neurology, 58: 840–846. doi: 10.1002/ana.20703

Author Information

  1. 1

    Free University, Amsterdam, the Netherlands

  2. 2

    National Multiple Sclerosis Society and Scientific and Clinical Review Associates, LLC, New York, NY

  3. 3

    Centre Hospitalier Regional Universitaire Rennes, Rennes, France

  4. 4

    Neuroimaging Research Unit, Department of Neurology, University Hospital San Raffaele, Milan, Italy

  5. 5

    Department of Neurology, Heinrich-Heine-Universität, Düsseldorf, Germany

  6. 6

    Departments of Neurology and Research, University Hospital, Basel, Switzerland

  7. 7

    Mount Sinai School of Medicine, New York, NY

  8. 8

    Foothills Medical Centre, Calgary, Alberta, Canada

  9. 9

    National Institute of Neurological Disorders and Stroke, Bethesda, MD

  10. 10

    St. Michael's Hospital, Toronto, Ontario, Canada

  11. 11

    University Hospital, Lund, Sweden

  12. 12

    Institute of Neurology, London, United Kingdom

  13. 13

    Mayo Clinic College of Medicine, Rochester, MN

  14. 14

    University of Texas Health Sciences Center, Houston, TX

*Department of Neurology, VU Medical Center Amsterdam, PO Box 7057, 1007 MB Amsterdam, the Netherlands

Publication History

  1. Issue published online: 28 NOV 2005
  2. Article first published online: 10 NOV 2005
  3. Manuscript Accepted: 3 SEP 2005
  4. Manuscript Revised: 24 AUG 2005
  5. Manuscript Received: 29 JUN 2005

Funded by

  • US National Multiple Sclerosis Society
  • Multiple Sclerosis International Federation
  • Multiple Sclerosis Society of Ireland

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Abstract

New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in 2001. The “McDonald Criteria” have been extensively assessed and used since 2001. New evidence and consensus now strengthen the role of these criteria in the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive disease. The 2005 Revisions to the McDonald Diagnostic Criteria for MS should simplify and speed diagnosis, whereas maintaining adequate sensitivity and specificity. Ann Neurol 2005

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