Original Article

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

  1. Ranjan Dutta PhD1,§,
  2. Jennifer McDonough PhD1,†,§,
  3. Xinghua Yin MD1,
  4. John Peterson PhD1,
  5. Ansi Chang MD1,
  6. Thalia Torres BS1,
  7. Tatyana Gudz PhD1,‡,
  8. Wendy B. Macklin PhD1,
  9. David A. Lewis MD3,
  10. Robert J. Fox MD2,
  11. Richard Rudick MD2,
  12. Karoly Mirnics MD3,
  13. Bruce D. Trapp PhD1,*

Article first published online: 3 JAN 2006

DOI: 10.1002/ana.20736

Issue

Annals of Neurology

Annals of Neurology

Volume 59, Issue 3, pages 478–489, March 2006

Additional Information

How to Cite

Dutta, R., McDonough, J., Yin, X., Peterson, J., Chang, A., Torres, T., Gudz, T., Macklin, W. B., Lewis, D. A., Fox, R. J., Rudick, R., Mirnics, K. and Trapp, B. D. (2006), Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol., 59: 478–489. doi: 10.1002/ana.20736

Author Information

  1. 1

    Department of Neurosciences, Lerner Research Institute

  2. 2

    Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH

  3. 3

    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA

  1. †

    Oak Clinic for MS Research at Kent State University, Kent, OH

  2. ‡

    Department of Neurobiology, Medical University of South Carolina, Charleston, SC

  1. §

    R.D. and J.M. contributed equally to this study.

*Department of Neurosciences/NC30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

  1. §

    R.D. and J.M. contributed equally to this study.

Publication History

  1. Issue published online: 17 FEB 2006
  2. Article first published online: 3 JAN 2006
  3. Manuscript Revised: 6 OCT 2005
  4. Manuscript Accepted: 6 OCT 2005
  5. Manuscript Received: 16 AUG 2005

Funded by

  • NIH (National Institute on Neurological Disorders and Stroke). Grant Numbers: NS35058, NS38667
  • National Multiple Sclerosis Society postdoctoral fellowship

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View Full Article with Supporting Information (HTML) Get PDF (1302K)