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Abstract

Objective

Migraine is associated with epilepsy, but the time order and nature of the relationship are unclear. We conducted a population based case control study to clarify the time order to determine whether migraine is a risk factor for epilepsy.

Methods

Migraine symptoms were evaluated in a population-based case–control study of all incident epilepsy in Icelandic children and in matched controls (next two same sex births in the country).

Results

Migraine was associated with a fourfold increased risk for developing epilepsy, an association explained by migraine with aura (odds ratio, 8.1; 95% confidence interval, 2.7–24.3). Migraine without aura did not increase risk for epilepsy.

Interpretation

Children with migraine with aura have a substantial increased risk to develop subsequent epilepsy. This finding is consistent with the hypothesis that migraine with aura and migraine without aura may be different disorders. Ann Neurol 2006;59:210–213