P.L. and D.C.H. contributed equally to this study.
Migraine with aura is a risk factor for unprovoked seizures in children
Article first published online: 22 DEC 2005
Copyright © 2005 American Neurological Association
Annals of Neurology
Volume 59, Issue 1, pages 210–213, January 2006
How to Cite
Ludvigsson, P., Hesdorffer, D., Olafsson, E., Kjartansson, O. and Hauser, W. A. (2006), Migraine with aura is a risk factor for unprovoked seizures in children. Ann Neurol., 59: 210–213. doi: 10.1002/ana.20745
- Issue published online: 22 DEC 2005
- Article first published online: 22 DEC 2005
- Manuscript Accepted: 15 OCT 2005
- Manuscript Received: 27 SEP 2005
- NIH (National Institute of Neurological Disorders and Stroke). Grant Number: 5R01 NS 32663
Migraine is associated with epilepsy, but the time order and nature of the relationship are unclear. We conducted a population based case control study to clarify the time order to determine whether migraine is a risk factor for epilepsy.
Migraine symptoms were evaluated in a population-based case–control study of all incident epilepsy in Icelandic children and in matched controls (next two same sex births in the country).
Migraine was associated with a fourfold increased risk for developing epilepsy, an association explained by migraine with aura (odds ratio, 8.1; 95% confidence interval, 2.7–24.3). Migraine without aura did not increase risk for epilepsy.
Children with migraine with aura have a substantial increased risk to develop subsequent epilepsy. This finding is consistent with the hypothesis that migraine with aura and migraine without aura may be different disorders. Ann Neurol 2006;59:210–213