Periventricular leukomalacia specifically affects cortical MEG response to biological motion
Article first published online: 10 JAN 2006
Copyright © 2005 American Neurological Association
Annals of Neurology
Volume 59, Issue 2, pages 415–419, February 2006
How to Cite
Pavlova, M., Marconato, F., Sokolov, A., Braun, C., Birbaumer, N. and Krägeloh-Mann, I. (2006), Periventricular leukomalacia specifically affects cortical MEG response to biological motion. Ann Neurol., 59: 415–419. doi: 10.1002/ana.20762
- Issue published online: 25 JAN 2006
- Article first published online: 10 JAN 2006
- Manuscript Accepted: 25 OCT 2005
- Manuscript Revised: 20 SEP 2005
- Manuscript Received: 10 MAY 2005
- German Research Foundation. Grant Numbers: KR 1316/5-P, SFB55O, C6
- Medical School of Eberhard-Karls-Universität Tübingen
Periventricular leukomalacia (PVL) underlies most of the neurological morbidity including visual-perceptual deficits in survivors of premature birth. However, it is unknown whether and, if so, how PVL affects functional cortical activity.
Here, we assessed changes in the magnetoencephalographic (MEG) response to visual displays depicting human locomotion in adolescents who were born premature with magnetic resonance imaging signs of PVL.
Dynamics of MEG activity parallel behavioral deficits. Early (140–170 milliseconds) brain activation over the right parietal cortex was weaker in patients compared with term-born controls.
This is the first evidence for stimulus-specific modulation of cortical activity by periventricular lesions providing new insights into the functional pathology of PVL. Ann Neurol 2006