Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis
Version of Record online: 1 FEB 2006
Copyright © 2006 American Neurological Association
Annals of Neurology
Volume 59, Issue 3, pages 566–569, March 2006
How to Cite
Weinshenker, B. G., Wingerchuk, D. M., Vukusic, S., Linbo, L., Pittock, S. J., Lucchinetti, C. F. and Lennon, V. A. (2006), Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis. Ann Neurol., 59: 566–569. doi: 10.1002/ana.20770
- Issue online: 17 FEB 2006
- Version of Record online: 1 FEB 2006
- Manuscript Accepted: 27 OCT 2005
- Manuscript Revised: 22 JUL 2005
- Manuscript Received: 19 JUL 2005
We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis.
Prospective study of patients with initial LETM who were tested for the presence of NMO-IgG.
Eleven of 29 patients (37.9%) were seropositive after a first attack of LETM spanning three or more vertebral segments on magnetic resonance imaging. Of 23 patients followed up for 1 year, none of 14 who were seronegative experienced a relapse or developed optic neuritis. Of 9 seropositive patients, 5 developed a second event: 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis (p = 0.004).
LETM represents an inaugural or limited form of NMO in a high proportion of patients. The 40% of patients who are seropositive for NMO-IgG are at high risk for relapse. Ann Neurol 2006