Evolution of cerebral arteriopathies in childhood arterial ischemic stroke
Version of Record online: 31 JAN 2006
Copyright © 2006American Neurological Association
Annals of Neurology
Volume 59, Issue 4, pages 620–626, April 2006
How to Cite
Danchaivijitr, N., Cox, T. C., Saunders, D. E. and Ganesan, V. (2006), Evolution of cerebral arteriopathies in childhood arterial ischemic stroke. Ann Neurol., 59: 620–626. doi: 10.1002/ana.20800
- Issue online: 24 MAR 2006
- Version of Record online: 31 JAN 2006
- Manuscript Accepted: 12 DEC 2005
- Manuscript Revised: 8 DEC 2005
- Manuscript Received: 9 JUN 2005
- R&D funding received from the NHS Executive
To investigate evolution of cerebral arteriopathy in children with arterial ischemic stroke (AIS) and its influence on recurrence.
Arteriopathy severity was graded on serial magnetic resonance angiograms from 50 children with first AIS; diagnostic categories were assigned.
Arteriopathy affected 72 arteries in 43 of 50 children. Five had clinical recurrence, with reinfarction in four; another had clinically silent reinfarction. Twelve children (24%; 4 with recurrence) had progressive arteriopathy. Arteriopathy improved in 24 patients (including 1 with recurrent transient ischemic attacks) and was stable in 7 patients. Magnetic resonance angiograms remained normal in seven patients; one had recurrent stroke. Diagnoses were transient cerebral arteriopathy (n = 24), chronic cerebral arteriopathy (n = 11), arterial dissection (n = 3), possible moyamoya (n = 2), primary moyamoya (n = 1), dysplastic arteriopathy (n = 1), and cerebral vasculitis (n = 1). Some of the first two categories could represent thromboembolic arterial occlusion with recanalization. The hazard of recurrence was three times higher when arterial disease had progressed (Cox regression hazard ratio, 3.2; 95% confidence intervals, 0.5–20.3; p = 0.22). After adjustment for age and number of AIS risk factors, the hazard ratio was 3.1 (95% confidence interval, 0.4–22.2; p = 0.27).
Arteriopathy frequently progresses after childhood AIS. Further studies are needed to examine the relationship between progressive arteriopathy and recurrence. Ann Neurol 2006