Members of the IPCG are listed in the Appendix on page 761.
International study on low-grade primary central nervous system lymphoma†
Article first published online: 3 APR 2006
Copyright © 2006 American Neurological Association
Annals of Neurology
Volume 59, Issue 5, pages 755–762, May 2006
How to Cite
Jahnke, K., Korfel, A., O'Neill, B. P., Blay, J.-Y., Abrey, L. E., Martus, P., Poortmans, P. M. P., Shenkier, T. N., Batchelor, T. T., Neuwelt, E. A., Raizer, J. J., Schiff, D., Pels, H., Herrlinger, U., Stein, H. and Thiel, E. (2006), International study on low-grade primary central nervous system lymphoma. Ann Neurol., 59: 755–762. doi: 10.1002/ana.20804
- Issue published online: 21 APR 2006
- Article first published online: 3 APR 2006
- Manuscript Accepted: 16 DEC 2005
- Manuscript Revised: 25 NOV 2005
- Manuscript Received: 24 AUG 2005
- German Cancer Aid (Deutsche Krebshilfe). Grant Number: 70-2838
The aim of this study was to characterize the clinical presentation, course, and outcome of low-grade primary central nervous system lymphoma.
Cases were assessed in a retrospective series collected from 18 cancer centers in 5 countries.
Forty patients (18 men, 22 women; median age, 60 years [range, 19–78]) were identified. Involvement of a cerebral hemisphere or deeper brain structures was seen in 37 patients, only leptomeningeal involvement in 2 patients, and spinal cord disease in 1 patient. Chemotherapy/radiotherapy was conducted in 15 patients, radiotherapy alone in 12, chemotherapy alone in 10, and tumor resection alone in 2, whereas 1 patient received no treatment. The median progression-free, disease-specific, and overall survival were 61.5 (range, 0–204), 130 (range, 1–204), and 79 (range, 1–204) months, respectively. Only age 60 years or older was associated with shorter progression-free (p = 0.009), disease-specific (p = 0.015), and overall survival (p = 0.001) in multivariate analysis.
Low-grade primary central nervous system lymphoma differs from the high-grade subtype in its pathological, clinical, and radiological features. It has a better long-term outcome than primary central nervous system lymphoma in general with age 60 years or older adversely affecting survival. Ann Neurol 2006