Pesticide exposure and risk for Parkinson's disease
Version of Record online: 26 JUN 2006
Copyright © 2006 American Neurological Association
Annals of Neurology
Volume 60, Issue 2, pages 197–203, August 2006
How to Cite
Ascherio, A., Chen, H., Weisskopf, M. G., O'Reilly, E., McCullough, M. L., Calle, E. E., Schwarzschild, M. A. and Thun, M. J. (2006), Pesticide exposure and risk for Parkinson's disease. Ann Neurol., 60: 197–203. doi: 10.1002/ana.20904
- Issue online: 21 JUL 2006
- Version of Record online: 26 JUN 2006
- Manuscript Accepted: 28 APR 2006
- Manuscript Received: 25 JAN 2006
- Michael J. Fox Foundation
- Kinetic Foundation
- National Institute of Environmental Health Sciences. Grant Number: ES10804
Chronic, low-dose exposure to pesticides is suspected to increase the risk for Parkinson's disease (PD), but data are inconclusive.
We prospectively examined whether individuals exposed to pesticides have higher risk for PD than those not exposed. The study population comprised participants in the Cancer Prevention Study II Nutrition Cohort, a longitudinal investigation of US men and women initiated in 1992 by the American Cancer Society. Follow-up surveys were conducted in 1997, 1999, and 2001. The 143,325 individuals who returned the 2001 survey and did not have a diagnosis or symptoms of PD at baseline (1992) were included in the analyses.
Exposure to pesticides was reported by 7,864 participants (5.7%), including 1,956 farmers, ranchers, or fishermen. Individuals exposed to pesticides had a 70% higher incidence of PD than those not exposed (adjusted relative risk, 1.7; 95% confidence interval, 1.2–2.3; p = 0.002). The relative risk for pesticide exposure was similar in farmers and nonfarmers. No relation was found between risk for PD and exposure to asbestos, chemical/acids/solvents, coal or stone dust, or eight other occupational exposures.
These data support the hypothesis that exposure to pesticides may increase risk for PD. Future studies should seek to identify the specific chemicals responsible for this association. Ann Neurol 2006