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Prognostic value of initial magnetic resonance imaging growth rates for World Health Organization grade II gliomas

  1. Johan Pallud MD1,
  2. Emmanuel Mandonnet MD, PhD1,2,
  3. Hugues Duffau MD, PhD1,2,
  4. Michèle Kujas MD, PhD3,
  5. Rémy Guillevin MD2,4,
  6. Damien Galanaud MD, PhD4,
  7. Luc Taillandier MD, PhD5,
  8. Laurent Capelle MD1,2,*

Article first published online: 18 SEP 2006

DOI: 10.1002/ana.20946

Issue

Annals of Neurology

Annals of Neurology

Volume 60, Issue 3, pages 380–383, September 2006

Additional Information

How to Cite

Pallud, J., Mandonnet, E., Duffau, H., Kujas, M., Guillevin, R., Galanaud, D., Taillandier, L. and Capelle, L. (2006), Prognostic value of initial magnetic resonance imaging growth rates for World Health Organization grade II gliomas. Ann Neurol., 60: 380–383. doi: 10.1002/ana.20946

Author Information

  1. 1

    Service de Neurochirurgie, Hôpital de la Pitié-Salpêtrière, Paris, France

  2. 2

    U678 Institut National de la Santé et de la Recherche Médicale, Hôpital de la Pitié-Salpêtrière, Paris, France

  3. 3

    Service de Neuropathologie, Hôpital de la Pitié-Salpêtrière, Paris, France

  4. 4

    Service de Neuroradiologie, Hôpital de la Pitié-Salpêtrière, Paris, France

  5. 5

    Service de Neurologie, Centre Hospitalier Universitaire de Nancy, Nancy, France

*Department of Neurosurgery, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75651 Paris cedex 13, France

Publication History

  1. Issue published online: 18 SEP 2006
  2. Article first published online: 18 SEP 2006
  3. Manuscript Accepted: 7 JUL 2006
  4. Manuscript Revised: 30 MAY 2006
  5. Manuscript Received: 14 MAR 2006

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Abstract

A consecutive series of 143 unselected adult patients with histologically proved World Health Organization grade II gliomas was reviewed to assess the prognostic value of growth rates of mean tumor diameters on successive magnetic resonance images before treatment. There is an inverse correlation between growth rates and survival (p < 0.001; median survival at 5.16 years for a growth rate of 8mm/year or more; median survival >15.0 years for a growth rate <8mm/year). Thus, individual magnetic resonance imaging tumor growth rates should be incorporated in the planning of the initial therapeutic strategy of grade II gliomas. Ann Neurol 2006;60:380–383

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