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Hemispherectomy for intractable epilepsy in adults: The first reported series

Authors

  • Shearwood McClelland III MD,

    Corresponding author
    1. Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN
    • Department of Neurosurgery, University of Minnesota, Mayo Mail Code 96, 420 Delaware Street SE, Minneapolis, MN 55455
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  • Robert E. Maxwell MD, PhD

    1. Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN
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Abstract

Hemispherectomy for intractable unihemispheric epilepsy (IUE) has long been established in pediatric patients. This study reports the first series examining hemispherectomy exclusively in adult patients (>18 years old). Nine adults with IUE underwent hemispherectomy at the University of Minnesota. All patients had unilateral hemiplegia and visual field loss. Seven patients (77.8%) were Engel class I/II at last follow-up. Five (83.3%) of the six patients with >30 years of follow-up were seizure free. No surgery-related mortality, hydrocephalus, or superficial cerebral hemosiderosis occurred. Hemispherectomy is an effective procedure in appropriately selected adult patients, resulting in excellent long-term seizure control and no mortality. Ann Neurol 2007

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