Inclusion body myositis with human immunodeficiency virus infection: Four cases with clonal expansion of viral-specific T cells
Article first published online: 15 MAR 2007
Copyright © 2007 American Neurological Association
Annals of Neurology
Volume 61, Issue 5, pages 466–475, May 2007
How to Cite
Dalakas, M. C., Rakocevic, G., Shatunov, A., Goldfarb, L., Raju, R. and Salajegheh, M. (2007), Inclusion body myositis with human immunodeficiency virus infection: Four cases with clonal expansion of viral-specific T cells. Ann Neurol., 61: 466–475. doi: 10.1002/ana.21103
- Issue published online: 27 APR 2007
- Article first published online: 15 MAR 2007
- Manuscript Accepted: 22 JAN 2007
- Manuscript Revised: 18 JAN 2007
- Manuscript Received: 30 OCT 2006
- Intramural Research Program of the NIH (National Institute of Neurological Disorders and Stroke)
Sporadic inclusion body myositis (sIBM), a common adult-onset myositis, is characterized by an antigen-driven inflammatory response and vacuolar degeneration. The cause is unknown. We report the association of sIBM with human immunodeficiency virus (HIV) infection and explore the clonality and viral specificity of the autoinvasive T cells.
Clinicopathological studies in four HIV-infected patients with IBM were performed. The clonal restriction of endomysial T cells, compared with peripheral blood, was examined by spectratyping. Immunohistochemical studies using human leukocyte antigen-A* 0201-gag tetramers and the most dominant Vb families were performed in serial muscle biopsy sections to examine whether clonally expanded autoinvasive T cells are viral specific and invade muscle fibers expressing the allele-specific monomorphic major histocompatibility complex class I antigen.
Prominent clonal restriction of certain Vb families was noted among the endomysial T cells with evidence of in situ expansion. Approximately 10% of the autoinvasive CD8+ cells were human leukocyte antigen-A* 0201-HIV-gag specific and invaded muscle fibers expressing the specific human leukocyte antigen-A* 0201 allele. These cells belonged to restricted Vb families. The HIV gag antigen was present on several endomysial macrophages but not within the muscle fibers.
sIBM develops in patients who harbor HIV. In HIV-IBM, a subset of CD8+ T cells surrounding muscle fibers are viral specific and may play a role in the disease mechanism by cross-reacting with antigens on the surface of muscle fibers. This study provides a paradigm that a chronic viral infection in genetically susceptible individuals can trigger viral specific T cell clones that persist within the muscle and lead to development of sIBM. Ann Neurol 2007