1531-8249/asset/cover.gif?v=1&s=685ec69724c5ed4c8847ce939e70ceb45065856f "Annals of Neurology")
Dr D. Cardebat is deceased.
1531-8249/asset/olbannerleft.gif?v=1&s=d36d5ebb3caa1b29d7f078a97c52973b0963daf2)
1531-8249/asset/olbannerright.gif?v=1&s=078041b213f6959d63575a593f880457c45116f0)
Brief Communication
Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy
Article first published online: 13 MAR 2007
DOI: 10.1002/ana.21110
Copyright © 2007 American Neurological Association
Additional Information
How to Cite
Brefel-Courbon, C., Payoux, P., Ory, F., Sommet, A., Slaoui, T., Raboyeau, G., Lemesle, B., Puel, M., Montastruc, J.-L., Demonet, J.-F. and Cardebat, D. (2007), Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy. Ann Neurol., 62: 102–105. doi: 10.1002/ana.21110
- †
Dr D. Cardebat is deceased.
Publication History
- Issue published online: 27 JUL 2007
- Article first published online: 13 MAR 2007
- Manuscript Accepted: 2 FEB 2007
- Manuscript Revised: 16 JAN 2007
- Manuscript Received: 5 DEC 2006
- Abstract
- Article
- References
- Cited By
Abstract
We conducted a randomized, double-blind, placebo-controlled, single-patient (N = 1) trial to evaluate the efficacy of zolpidem in a 48-year-old woman with an akinetic mutism. Motor and cognitive examinations and functional imaging were performed. Acute administration of zolpidem markedly improved motor performance and neuropsychological status. Cerebral metabolism (18F-fluorodeoxyglucose positron emission tomography) increased in postrolandic territories and in frontal cortex. Using the H215O positron emission tomography, we found a drug-induced activation in the anterior cingulate and orbitofrontal cortices. Zolpidem induced a transient improvement in motor and cognitive performances. This paradoxical effect could result from an activation of limbic loops modulating motivational processes. Ann Neurol 2007